One case of acute lymphoblastic leukemia with del(5q) and literatures review
10.3760/cma.j.issn.1009-9921.2012.09.010
- VernacularTitle:伴有5号染色体长臂缺失的急性淋巴细胞白血病一例并文献复习
- Author:
Yulong LI
;
Wei CHENG
;
Lei ZHANG
;
Lin ZHANG
;
Lushe LIU
;
Yaping ZHAI
- Publication Type:Journal Article
- Keywords:
Leukemia biphenotypic,acute;
Chromasome deletion
- From:
Journal of Leukemia & Lymphoma
2012;21(9):543-546
- CountryChina
- Language:Chinese
-
Abstract:
Objective To introduce the laboratory and clinical characteristics of acute lymphoblastic leukemia accompanied by the karyotypic abnormality of 5q-.Methods Report the diagnosis and treatment of one case of acute lymphoblastic leukemia with 5q- and review the relevant literatures.Results The patient came to the hospital because of bellyache and ostalgia.The blood routine showed a high WBC count and reduced platelets.Bone marrow aspirates examination indicated acute leukemia and by peroxidase staining and flow cytometry test,acute pro-T lymphoblastic leukemia was diagnosed.The karyotype and fluorescence in situ hybridization analysis showed 5q-.The hyper-CVAD regimen induced a temporary remission but it did not work anymore after the relapse nor did the MEA regimen.From the literatures ever reported,the kyryotypic abnormality of 5q- was rarely seen in acute lymphoblastic leukemia.In such cases,the minimal deletion region overlaped between marks of D5S410 and D5S436 corresponding to chromosomal location 5q31-33.Conclusion 5q- is rare in acute lymphoblastic leukemia and more features are still to be found about the kind of disorder.
