Analysing the clinical characteristics and prognostic factors of 56 eases of primary anaplastic large cell lymphoma
10.3760/cma.j.issn.1009-9921.2008.03.006
- VernacularTitle:原发系统型间变性大细胞淋巴瘤56例临床特征和预后相关因素分析
- Author:
Yanli YANG
;
Zifen GAO
;
Chunju ZHOU
;
Yunfei SHI
;
Jing WANG
;
Xiaoyan KE
- Publication Type:Journal Article
- Keywords:
Primary systemic anaplastic large cell lymphoma;
Prognosis;
ALK;
bcl-2
- From:
Journal of Leukemia & Lymphoma
2008;17(3):178-181
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study clinical characteristics and prognostic factors in primary systemic anaplastic large cell lymphoma (S-ALCL). Methods Clinical data of 56 S-ALCL were retrospectively analysed, who were diagnosed in Lymphoma Lab of Peking University Health Science Centre. Immunohistochemical staining for ALK-1 and bcl-2 were performed by standard SP method. Results The median age of patients is 17 years, and the ratio of sex was1.67:1 (male : female) in 56 cases of S-ALCL. Among of the 49 cases who were followed up, 32.65 % (16/49) of patients died, and all of them died within two years after diagnosis. The 3-year and 5-year overall survival were 64.28 %. 41 out of 56 cases (73.21 %) was positive for ALK-1 protein, while 10 cases out of 56 S-ALCL cases (17.86 %) positive for bcl-2. Clinical staging, extranodal sites of involvement or with extranodal sites of involvement and ALK were important prognostic factors with statistic significance by Long-rank test. Among of them, Clinical staging was the most independent prognostic factor by COX multivariate analysis. Conclusion S-ALCL was mostly seen in the young and middle-aged male patients. The death were most frequently occurred within two years after diagnosis. Most of the patients who have good responses to chemotherapy can get the complete remission and long-term survival. Clinical staging, extranodal sites of involvement or with extranodal sites of involvement and ALK were very important prognostic factors which can be used to predict the patients long term survival, and guide the treatment.
