Clinical value of combined detection of urinary microproteins in acute promyelocytic leukemia with arsenic trioxide in childhood
10.3760/cma.j.issn.1009-9921.2010.11.005
- VernacularTitle:尿微量蛋白联合检测在三氧化二砷治疗小儿急性早幼粒细胞白血病中的临床价值
- Author:
Liangchun HAO
;
Jishun ZHAO
;
Xiuli WANG
;
Hong WANG
;
Huan WANG
;
Gang XU
- Publication Type:Journal Article
- Keywords:
Promyelocytic,leukemia,acute;
Arsenicals;
Kidney function tests;
Urinary microproteins;
Childhood
- From:
Journal of Leukemia & Lymphoma
2010;19(11):658-660
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the renal toxicity of arsenic trioxide (As2O3) with therapeutic dose in acute promyelocytic leukemia (APL) in childhood. Methods Renal toxicity of 37 APL was monitored. The examinations of urinary routine, urinary microproteins[αt1-microglobulin (α1-MG), microalbumin (mAlb),β2-microglobulin (β2-MG), transferrin(TRF)] and renal function were performed. Results Five cases with leukocyturia, three cases with hematuria, six cases with proteinuria were observed before therapy. Ketonuria occurred in six cases associated with fever and less diet; overall abnormality disappeared in the first week. No significant changes of blood uric nitrigen(BUN), serum creatinine(Cr) and uric acid (UA) were founded in induction remission. Compared with tests before As2O3 infusion, obvious increase of uric α1-MG occurred in second week with arsenic trioxide, obvious increase of uric β2-MG in third week (P ＜0.01), slow recovery of uric α1-MG and β2-MG in fifth week. No significant changes of uric mAlb and TRF were seen in induction remission. Conclusion The renal toxicity of As2O3 was gentle in general therapeutic dose, renal tubercular damage could be seen. The important monitoring period were the second to fifth week in induction remission.Influence of As2O3 cumulant on renal function was not serious in the near future in childhood. The combined detection of urinary microproteins with dynamic variety could detect early renal damage with As2O3.
