Expressions of p33ING1, ER, PR and c-erbB-2 in Thyroid Carcinomas
10.3969/j.issn.0253-9896.2009.07.005
- VernacularTitle:甲状腺癌中p33ING1、ER、PR和c-erbB-2的表达及意义
- Author:
Kelun CHENG
- Publication Type:Journal Article
- Keywords:
thyroid neoplasms;
carcinoma genes,tumor suppressor;
receptors,estrogen;
receptors,progesterone;
receptor,erbB-2;
immunohistochemistry;
gene expression
- From:
Tianjin Medical Journal
2009;37(7):541-543
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the expressions of p33ING1, estrogen receptor(ER),progestrone receptor(PR) and c-erbB-2 in the specimens of thyroid carcinomas. Methods:The immunohistochemical methods(SP) were used to detect the expressions ofp33ING1',ER,PR and c-erbB-2 in specimens of thyroid adenomas (TA) and thyroid carcinomas (TC). Results:The positive expression rates of p33ING1, ER, PR and c-erbB-2 protein were76.5%,35.0%,40.0% and 5.0% in TA; and 41.2%,57.8%,64.4%and 46.7% in TC, respectively. There was a significant difference between groups (P＜0.05 or P＜0.01). There was a negative correlation between expressions of e-erbB-2 protein and p33ING1, ER, PR(r=-0.218, -0.221, -0.213, P＜0.01). Conclusion:It may play an important role that p33ING1, ER, PR and e-erbB-2 protein in occurrence and development of thyroid carcinoma,and they may be factors to predict the prognosis of thyroid carcinoma.
