Unrelated donor hematopoietic stem cell transplantation for the treatment of severe aplastic anemia
10.3760/cma.j.issn.1009-9921.2010.05.021
- VernacularTitle:再生障碍性贫血无关供者造血干细胞移植治疗进展
- Author:
Huimin CAO
- Publication Type:Journal Article
- Keywords:
Anemia,aplastic;
Hematopoietic stem cell transplantation;
Therapy
- From:
Journal of Leukemia & Lymphoma
2010;19(5):316-319
- CountryChina
- Language:Chinese
-
Abstract:
In the recent years, with the improvement of conditioning regimens, the prevalence of high-resolution HLA matching, as well as the application of high-intensity broad-spectrum antibiotics, unrelated donor transplantation for the treatment of severe aplastic anemia has been improved significantly, with lower incidences of graft failure, graft-versus-host disease, infectious complications, etc. Studies have already confirmed that transplantation from an unrelated donor should be recommended as an effective therapy for children and young adults who do not respond to the first course of immunosuppressive therapy.
