The development of novel tyrosine kinase inhibitors
10.3760/cma.j.issn.1009-9921.2008.04.030
- VernacularTitle:新型酪氨酸激酶抑制剂研究进展
- Author:
Hongying CHAO
;
Ri ZHANG
- Publication Type:Journal Article
- Keywords:
Protein-tyrosine rinases;
Leukemia,myeloid,chronic;
Drug resistance,neoplasms
- From:
Journal of Leukemia & Lymphoma
2008;17(4):316-318
- CountryChina
- Language:Chinese
-
Abstract:
At the end of last century,the snlall-molecule selective kinase inhibitor,imatinib mesylate (IM),Was successfully exploited.This resulted in a revolutionary step in the treatment of chronic myeloid leukemia(CML).However,along with the expansion of its clinical application and the process,drug resistance Was commonly observed in patients, especially during accelerated or blast phases, and has become a significant therapeutic problem in clinical application.The problem has prompted the appearance of novel small molecule tyrosine kinase inhibitors,and its development is reviewed.
