Comparison of therapeutic efficacy among 3 different regimens of neoadjuvant chemotherapy for FIGO stage Ⅰb2-Ⅱb cervical squamous carcinoma before operation
- VernacularTitle:Ⅰb2～Ⅱb期宫颈鳞状细胞癌术前3种新辅助化疗的疗效比较
- Author:
Yuefeng FAN
;
Long JIN
;
Nan HONG
;
Jian GAO
;
Lei CHEN
;
Jianliu WANG
;
Xiangke DU
- Publication Type:Journal Article
- Keywords:
Carcinoma,squamous cell;
Cervix uteri;
Neoadjuvant chemotherapy
- From:
Chinese Journal of Interventional Imaging and Therapy
2010;7(2):133-136
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the short-time effect of 3 different regimens of neoadjuvant chemotherapy (NACT) in patients with FIGO stage Ⅰb2-Ⅱb cervical squamous carcinoma.Methods A total of 50 patients with FIGO stage Ⅰb2-Ⅱb cervical squamous carcinoma were divided into 3 groups:systemic chemotherapy group (n=13) ,trans-arterial chemotherapy group (TAC,n=19) ,trans-arterial chemoembolization group (TACE,n=18) .After 1-3 periods of NACT,all patients received surgical operation.Tumor response and reduction ratio after NACT,side effects,hemorrhage volume in surgery and bad prognostic factors (including intraluminal tumor thrombi,pelvic lymph node metastasis,parametrial involvernent,positive surgical margin,ovary metastasis) of operation sample were statistically analyzed.Results Tumor response,reduction ratio and hemorrhage volume in surgery were significantly better in TAC group and TACE group than those in systemic chemotherapy group (P＜0.05) ,but no significant difference was found between TAC group and TACE group (P＞0.05) .The incidence rate of intraluminal tumor thrombi and lymph node metastasis was lower in TACE group than in systemic chemotherapy group and TAC group,but there was no statistical difference.No difference of parametrial involvement,positive surgical margin,ovary metastasis and side effects was found among 3 groups.Conclusion For stage Ⅰb2-Ⅱb cervical squamous carcinoma,preoperative TAC and TACE have more advantages than systemic chemotherapy.In comparison with TAC,TACE is expected to reduce the incidence rate of bad prognostic factors such as intraluminal tumor thrombi and pelvic lymph node metastasis.
