Expression of ALK-1, TIA-1 and granzyma B in primary systematic anaplastic large cell lymphoma and their significances on clinical outcome
10.3760/cma.j.issn.1009-9921.2008.02.012
- VernacularTitle:原发系统型间变性大细胞淋巴瘤ALK-1、TIA-1和granzyme B表达与预后
- Author:
Yunfei SHI
;
Chunju ZHOU
;
Cuiling LIU
;
Min LI
;
Xin HUANG
;
Gehong DONG
;
Yuanjie HUANG
;
Wenjuan YIN
;
Yanli YANG
;
Fang LIU
;
Xiaolong MA
;
Juan DU
;
Zifen GAO
- Publication Type:Journal Article
- Keywords:
Lymphoma,T-cell;
Immunohistochemistry;
Viral regulatory proteins;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2008;17(2):114-118
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of anaplastic lymphoma kinase (ALK-1) and cytotoxic proteins in primary systemic anaplastic large cell lymphoma (S-ALCL) and their relationship with clinical outcome. Methods 51 S-ALCL cases were collected from Lymphoma Lab of Peking University Health Science Centre & Peking Children's Hospital. The morphologic characteristics were studied under routine microscope, and essential immunohistochemical stainings were performed and reviewed to confirm the diagnosis of S-ALCL. Immunohistochemical stainings for ALK-1 and cytotoxic proteins (TIA-1 & granzyme B) were performed using standard SP method. Patients related clinical data including follow-up materials were collected. Results Survival time of 44 cases with completely clinical follow up materials ranged from 0.5～66months. 36 out of 51 cases(37 %) was positive for ALK-1 protein. While 20 cases out of 47 S-ALCL cases ( 42.55 % ) positive for granzyme B and 22 out of 28 cases (81.48 %) were positive for TIA-1. The prognosis of patients with ALK-1 protein positive and granzyme B negative expression was better, but TIA-1 expression might have nothing to do with clinical outcome (P＞0.05). In addition, multivariate analysis confirmed that ALK-1 protein expression, granzyme B protein expression and Ann-Arbor stage system were possible for prognosis(P＜0.05), Conclusion Expression of ALK-1 and granzyme B protein expression may serve as two independent prognostic predictors in S-ALCL patients.
