Cell death and malignant lymphoproliferative disorders regulated by bcl-2 family
10.3760/cma.j.issn.1009-9921.2012.04.021
- VernacularTitle:bcl-2家族调控的细胞死亡与恶性淋巴增殖性疾病
- Author:
Xiaodu XU
;
Ou JI
- Publication Type:Journal Article
- Keywords:
bcl-2;
Cells;
Lymphma;
Lymphoproliferative disorders
- From:
Journal of Leukemia & Lymphoma
2012;21(4):252-255
- CountryChina
- Language:Chinese
-
Abstract:
As important regulators of apoptosis,bcl-2-family proteins regulate all major types of cell death,including apoptosis,necrosis,and autophagy.It's known that impaired apoptosis is a critical step in tumor development.Overexpression of antiapoptotic proteins of bcl-2 family is associated with the development and prognoses of malignant lymphoproliferative disorders.
