Observation on brain default mode network in patients with Parkinson disease
10.3321/j.issn:1003-3289.2009.07.009
- VernacularTitle:帕金森病静息态脑默认状态网络的观察
- Author:
Bo LIU
;
Jun CHEN
;
Xian LIU
;
Yu LONG
;
Zhiguang CHEN
;
Ningna LI
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Resting state;
Magnetic resonance imaging;
Default mode network
- From:
Chinese Journal of Medical Imaging Technology
2009;25(7):1156-1159
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of brain default mode network of patients with Parkinson disease (PD) in resting state with functional MRI. Methods Fourteen PD patients and 14 matched controls were selected and posterior cingulate cortex was regardes as region of interest. Results Compared with control group, brain default mode network of PD patients in resting state was abnormal, including decreased functional connectivity and increased functional connectivity. The brain areas with decreased functional connectivity included left inferior parietal lobule, right precuneus, medial prefrontal and left superior temporal gyrus. The brain area of increased functional connectivity included left cerebellar tonsil, left postcentral gurus, left superior parietal lobule, left precuneus, right inferior temporal gyrus, right cuneus, right lingual gyrus and left middle temporal gurus. Conclusion The brain default mode network of PD patients is abnormal in resting state.
