Progression of proteasome inhibitor in the targeted therapy for hematological sistemetic malignant tumor
10.3760/cma.j.issn.1009-9921.2009.01.024
- VernacularTitle:蛋白酶体抑制剂在恶性血液病靶向治疗中的研究进展
- Author:
Yani LI
;
Liangming MA
- Publication Type:Journal Article
- Keywords:
Proteasome inhibitor;
Malignant hematonosis;
Apoptosis
- From:
Journal of Leukemia & Lymphoma
2009;18(1):60-63
- CountryChina
- Language:Chinese
-
Abstract:
Proteasomes is a multienzyme complex.It can degradate cyclin,which control the process of cell cycle and cell apoptosis.Proteasome inhibitor regulate cell cycle and promote cell apoptosis through suppressing UP pathway.Proteasome inhibitor can stimulate apoptosis of various hematological systemetic malignant tumor and cause cell apoptosis through different mechanism in vivo and vitro.Therefore,proteasome inhibitor is a new-style tumor targeted therapy drug.
