A study of 14 primary cutaneous anaplastic large cell lymphoma cases into their pathology features and relevance with clinical manifestations

VernacularTitle:原发性皮肤间变性大细胞淋巴瘤14例病理和临床分析
Author: Qiuyang LI ; Xiaoge ZHOU
Publication Type:Journal Article
Keywords: PC-ALCL; Morphology; Immunohistochemistry; WHO classification; Clinical manifestations; Prognosis
From: Journal of Leukemia & Lymphoma 2010;19(4):215-218
CountryChina
Language:Chinese
Abstract: Objective To summarize the morphological and immunohistological and clinical manifestatical features of primary cutaneous anaplastic large cell lymphoma (PC-ALCL). Methods We analyzed retrospectively the morphological and immunohistological and clinical data of 14 cases with PC-ALCL and summarized their features. Results Fourteen cases of PC-ALCL were studied. Thirteen cases were followedup in which all cases were alive. There were 11 cases in common type which showed medium to large-sized cells with predominant pleomorphism, 2 cases in immunoblastic type and 1 case in small cell type. Immunohistochemical staining showed that more than 75 % tumor cells expressed CD30 in every case.Conclusion PC-ALCL is an uncommon subtype of lymphoma with an good prognosis. It is characterized by cutaneous nodules, the inflitartion of medium to large-sized cells and the diffuse expression of CD30.