Aspirin Resistance and Off-Pump Coronary Artery Bypass Grafting
10.3969/j.issn.0253-9896.2010.02.003
- VernacularTitle:非体外循环冠状动脉旁路移植术后阿司匹林抵抗现象的研究
- Author:
Fei GAO
;
Zanxin WANG
;
Jing REN
;
Jianlong MEN
;
Minxin WEI
- Publication Type:Journal Article
- Keywords:
coronary artery bypass,off pump;
aspirin;
platelet aggregation;
drug resistance
- From:
Tianjin Medical Journal
2010;38(2):87-89
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess aspirin efficacy in the early postoperative period following off-pump coronary artery bypass(OPCAB)surgery.Methods:Sixty patients undergoing OPCAB surgery were enrolled in the study.Previous aspirin treatment Was terminated 5-7 days before OPCAB and continued to take at the day with food intake after surgery.The functional and biochemical responses to aspirin were evaluated by arachidonie acid (ARA)-induced platelet aggregation.Samples were collected before and on days 1,4 and 10 after aspirin intake(100 mg/d).Results:There were 17 patients(28.3%),9 patients (15%)and 2 patients(3.3%)with aspirin resistance on day 1,4 and 10 of aspirin intake.The overall levels of platelet aggregation(%)were 63(52,70),13(11,22),12(10,14),and 12(11,14)before the surgery and on day 1,4 and 10 of aspirin intake.The level was stable from the 4th day after aspirin intake.It was found that aspirin resistance was not an independent risk factor for the operation.Conclusion:Aspirin did not sufficiently inhibit platelet aggregation at the early stage after OPCAB.It is important to keep potential anti-coagulation therapy in the early postoperative period.
