Dectection and risk factor analysis of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation
10.3760/cma.j.issn.1009-9921.2009.02.010
- VernacularTitle:恶性血液病患者异基因造血干细胞移植后巨细胞病毒感染的监测及危险因素分析
- Author:
Yong XU
;
Jian OUYANG
;
Jingyan XU
;
Bin CHEN
;
Rongfu ZHOU
;
Yonggong YANG
;
Qiguo ZHANG
;
Min ZHOU
;
Xiaoyan SHAO
;
Chaoyang GUAN
- Publication Type:Journal Article
- Keywords:
Hematologic neoplasms;
Hematopoietic stem cell transplantation;
Cytomegalovirus;
Polymerase chain reaction;
Risk factors
- From:
Journal of Leukemia & Lymphoma
2009;18(2):93-95
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the frequency and the course of cytomegalovims infection after allogeneic hematopoietic stem cell transplantation, and correlation of transplant factors with Cytomegalovirus (CMV) infection and viral load. Methods Using real-time polymerase chain reaction, we detected the copies of CMV-DNA in blood samples of the 62 patients after allo-HSCT. Furthermore, we studied the relationship between transplant factors and CMV infection. Results Among the total, 23 cases were contracted with CMV infection, 4 cases developed to CMV disease. 22 cases were cured and 1 case died. Course of CMV infection influenced the viral load significantly. Donor type, stem cell source, use of ATG, Ⅱ-Ⅳ grade aGVHD, use of glucocorticoid, complicating with other infection and use of cellular filter significantly influenced CMV infection. However, in multivariate analysis, none of them was the independent risk factors. Conclusion Real-time polymerase chain reaction may be used to early diagnose of the CMV infection and to guide treatment. Many factors influenced CMV infection. Early diagnosis and treatment could decrease the morbidity and mortality of CMV infection.
