Effect of autologous bone marrow cells transplantation on myocardial function in patients with acute myocardial infarction:A Doppler echocardiographic observation
- VernacularTitle:组织多普勒成像评价急性心肌梗死患者自体骨髓单个核细胞移植心功能
- Author:
Yunyan DUAN
;
Jun ZHANG
;
Liwen LIU
;
Xinmin HE
;
Xiaodong ZHOU
;
Haibin ZHANG
;
Chengxiang LI
;
Ting ZHU
;
Hongling LI
- Publication Type:Journal Article
- Keywords:
Tissue Doppler imaging;
Myocardial infarction;
Transplantation;
Ventricular function,left
- From:
Chinese Journal of Medical Imaging Technology
2010;26(3):476-479
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate left ventricular function of acute myocardial infarction (AMI) patients who underwent autologous bone marrow mononuclear cells (BMMNC) after percutaneous coronary intervention (PCI) transplantation with tissue Doppler imaging (TDI). Methods Forty-eight male patients with AMI were divided into experimental group and control group (each n=24). PCI was performed within 24 hours after attach. Patients in experimental group received autologous BMMNC transplantation 7-14 days after PCI. Conventional echocardiography and TDI were performed before and 1, 3 and 6 months after treatment. Left ventricular ejection fraction (LVEF), peak systolic (S_a, S_m), early diastolic (E_a, E_m) and late diastolic (A_a, A_m) mitral velocities and regional myocardial velocities were obtained with conventional echocardiography or TDI, and compared between the two groups. Results There was no significant difference of each index between two groups before operation. Compared with the control group, S_a, S_m, E_m, E_a/A_a and Em/Am improved significantly in experimental group at each follow-up time point; LVEF and E_a were significantly higher than those of control group 3 and 6 months after treatment. Conclusion Combination of PCI and autologous BMMNC transplantation is more helpful to improve regional and global cardiac systolic and diastolic function after myocardial infarction, which can be quantitatively evaluated with TDI.
