Deletions of chromosome 6q in two cases of acute myeloblastic leukemia and a review of the leterature
10.3760/cma.j.issn.1009-9921.2008.03.007
- VernacularTitle:伴有6号染色体长臂缺失的急性髓细胞白血病二例报告及文献复习
- Author:
Xiaomei HU
;
Xiaohong YANG
;
Hongzhi WANG
;
Chi LIU
;
Naiping HU
;
Yonggang XU
;
Feng LIU
;
Rou MA
- Publication Type:Journal Article
- Keywords:
Leukemia,myelocytic,acute;
Chromosome;
Immunophenotyping
- From:
Journal of Leukemia & Lymphoma
2008;17(3):182-186
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical and biologic characteristics of acute myeloid leukemia (AML) with 6q deletions (6q-). Methods Two cases of with 6q deletions (6q-) were here described, and all the AML cases with 6q- found in the literature were reviewed. Results Two cases were diagnosed with AMLMt and AML-M2, respectively. Myloloid markers were positive on the leukemia cells in both cases, none of them expressing lymphocytic antigens. The karyotype of these patients were 46,XX,del(6)(q21q25),t(4; 7)(q10;q10)[3]/46,XX,del(6)(q21q25)[2]/46,XX[25], and 46,XX,del(6)(q23),t(7;11)(p15;p15)[5]/46,XX,t(7;11)' (p15;p15)[9]/46,XX [6]. Until now, 28 cases (including present 2 cases) of AML with 6q- have been documented in the world literature. Many of the AML patients with 6q -have additional chromosomal abnormalities. The breakpoints on 6q- were widely distributed from q12 to q27, mainly involved in the 6q21-23 region. Overall, the AML patients with 6q- were associated with an unfavorable clinical outcome, with a poor response to chemotherapy and a shorter duration. 6q-clone may itself confer a malignant clinical outcome. The 6q- found in some AML cases may associate with leukemogenesis via an activation of an oncogene other than myb or deletion of an antioncogene located in the long arm of chromosome 6. Conclusion Deletion of 6q is a very rare event in AML. AML with 6q- had distinct biologic features and a. poor clinical outcome.
