Effect on erythrocyte reconstitution following ABO-incompatible allogeneic peripheral blood stem celltransplantation
10.3760/cma.j.issn.1009-9921.2011.11.008
- VernacularTitle:ABO血型不合对异基因外周血造血干细胞移植后红系重建的影响
- Author:
Ning XIE
;
Yuewen FU
;
Fengkuan YU
;
Baijun FANG
;
Yanli ZHANG
;
Jian ZHOU
;
Xudong WEI
;
Yongping SONG
- Publication Type:Journal Article
- Keywords:
Blood group incompatibility;
Hematopoietic stem cell transplantation;
Hematopoiesis
- From:
Journal of Leukemia & Lymphoma
2011;20(11):666-668
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the clinical characteristics in ABO-incompatible allogeneic peripheral blood stem cell transplantation(allo-PBSCT).Methods137 patients'clinical courses who accepted allo-PBSCT were retrospectively reviewed. Sixty-five cases of them were ABO-incompatible allo-PBSCT patients,including 32 ABO major mismatched cases,23 ABO minor mismatched cases and 10 ABO major and minor mismatched cases.Seventy-two ABO-identical cases were taken as control group.ResultsCompared with ABO-idential cases,the time of erythrocyte recovery after allo-PBSCT in ABO major and minor mismatched group was delayed [(73.2+10.3) d vs (97.5+10.4) d] (P ＜0.05).In ABO-incompatible group, the time of blood type switching in different ABO-incompatible types were found no significant difference (P ＞0.05) [ABO major mismatched:(45.7±17.3) d,ABO minor mismatched:(41.2+16.1) d and ABO major and minor mismatched:(48.4±20.9) d (P ＞ 0.05)].There were 8 cases who have a delayed time of blood type changing, including 6 cases demonstrated recipient-derived anti-A antibody. ConclusionABO-incompatible has no negative effect on allo-PBSCT.The time of erythrocyte reconstitution was delayed in ABO major and minor mismatched group.A delayed time of blood type switching tends to occur in ABO minor incompatible cases and patients who have anti-A antibody initially.
