Expression of TfR2 in the anemia of chronic disease of rats

VernacularTitle:转铁蛋白受体-2mRNA在慢性病贫血大鼠肝脏中的表达
Author: Yine WANG ; Mei FENG ; Xiao WANG
Publication Type:Journal Article
Keywords: Receptors,transferrin; Chronic disease; Anemia; Erythropoietin
From: Journal of Leukemia & Lymphoma 2009;18(4):206-209
CountryChina
Language:Chinese
Abstract: Objective Based on establishing a rat model of anemia of chronic disease (ACD), expression of transferrin receptor 2(TfR2) in the liver cultured with erthropoietin(EPO) and cultured without EPO to the action of TfR2 in the ACD were detected. Methods Anemia was induced by injecting freund adjuvant for third times to the traditional model rats of adjuvant arthritis to enhance their immune responses the levels of the expression level of TfR2 mRNA in the livers of rats among different treated groups were compared. Results In the ACD group the expression of TfR2 mRNA in the livers of rats was higher than in the normal control goup(P =0.001), is significant in anemia; while in the EPO therapy group the expression of TfR2 mRNA was less than in the ACD goup (P=0.001), is improved in anemia. Conclusion TfR2 may be revalant to ACD.