Progress on Notch signaling pathway in the B-cell malignancies
10.3760/cma.j.issn.1009-9921.2012.07.018
- VernacularTitle:Notch信号通路在B细胞恶性肿瘤中的研究进展
- Author:
Yanying LI
- Publication Type:Journal Article
- Keywords:
Notch;
B-lymphocytes;
Neoplasms;
Research
- From:
Journal of Leukemia & Lymphoma
2012;21(7):439-441
- CountryChina
- Language:Chinese
-
Abstract:
The Notch signaling pathway is a highly conserved classical developmental pathway,which plays a critical role in cell-fate decision by modulating proliferation, differentiation and apoptosis. There is increasing evidence that abnormal Notch pathway is correlated with occurrence and development of many tumors. Notch signaling plays dual roles in a wide range of B-cell malignancies. It serves as either an oncogene or a tumor suppressor. Notch signaling pathway may be a novel target for B-cell malignancies therapy.
