Expression and significance of IL-17 in multiple myeloma bone disease

VernacularTitle:多发性骨髓瘤骨病患者白细胞介素-17的表达及其意义
Author: Miao ZHANG ; Xiulian ZHANG ; Weihua ZHANG ; Xinghuo FAN ; Xiaojing GE ; Fang WEI ; Jie TAO
Publication Type:Journal Article
Keywords: Multiple myeloma bone disease; Interleukin-17; Receptor activator of nuclear factor-kappaB
From: Journal of Leukemia & Lymphoma 2012;21(5):282-284
CountryChina
Language:Chinese
Abstract: ObjectiveTo detect IL-17 level of bone marrow in patients with multiple myeloma bone disease,and to investigate its clinical significance.MethodsThe bone marrow IL-17 levels were quantified in 33 cases of multiple myeloma patients and 20 normal control by ELISA assay. RANKL mRNA expression were detected by using RT-PCR.ResultsIn bone marrow supernatant,IL-17 was detected in both groups,and RANKL mRNA were detected in both groups too. IL-17 and RANKL mRNA levels in bone marrow of patients with MM were significantly higher than those in the control group(P＜0.05). The bone marrow concentrations of IL-17 and bone marrow mononuclear cells' RANKL mRNA expression in active stage were significantly higher than those in stable stage (P＜0.05).The bone marrow IL-17 and RANKL were significantly correlated (r =690,P＜0.05).ConclusionIL-17 may play an important role in the pathogenesis of MM.