The function of epigenetic modification in human leukemia
10.3760/cma.j.issn.1009-9921.2010.05.020
- VernacularTitle:表观遗传修饰在白血病中的作用
- Author:
Chen YAO
- Publication Type:Journal Article
- Keywords:
Leukemia;
DNA methylation;
Histones
- From:
Journal of Leukemia & Lymphoma
2010;19(5):313-316
- CountryChina
- Language:Chinese
-
Abstract:
In the past few years, people have a new understanding of the mechanism of Epigenetic disease. Epigenetic modification processes involved in human disease include DNA methylation, histone acetylation and methylation, RNA-associated silencing.Epigenetic modification related with cell growth, differentiation, apoptosis, transformation and tumor progression-related gene transcription. There has been a long time that the gene mutations involved in tumor formation. In recent years.more and more evidences that genetic and epigenetic modifications leading to the formation of tumors. Epigenetic modifications has also play a very important role in the formation of tumors. This article discussed the DNA methylation.histone post-translational modification anomalies and small interference RNA impact on the formation of leukemia. It provides new prospects for the treatment of leukemia.
