Research progress of CD+4 CD+25 Foxp3+ regulatory T cell in T cell non-Hodgkin lymphoma

VernacularTitle:CD+4CD+25Foxp+3调节性T细胞在T细胞非霍奇金淋巴瘤中的研究进展
Author: Zenghui LIU
Publication Type:Journal Article
Keywords: T-lymphocytes,regulatory; Lymphoma,non-Hodgkin; Research
From: Journal of Leukemia & Lymphoma 2010;19(11):698-701
CountryChina
Language:Chinese
Abstract: CD+4 CD+25 regulatory T cell ( CD+4 CD+25 Treg) is a unique T-cell subsets with immune regulation function. Natural CD+4 CD+25 Treg originates from the thymus and acquired CD+4 CD+25 Treg can beinduced from CD+4 CD-25 T cells in peripheral blood. A specific transcription inhibitory factor-Foxp3 can be expressed, besides, it also can express other membrane molecules, such as CD4, CD25, CTLA-4 (CD152), GITR,etc. Its main function is immunosuppression and immune anergy. Recent research finds that it over-expresses in some non-Hodgkin lymphoma, and the number of CD+4 CD+25 Treg increases as tumor progression. The increased CD+4 CD+25 Treg can accelerate tumor growth and recurrence, and inhibit effector T cells (CD+4 T cells or CD+8 T cells), which makes it probably play a role in tumor immune escape mechanisms. In this article, the recent research results of CD+4 CD+25 Treg in T cell non-Hodgkin lymphoma (mainly cutaneous T-cell lymphoma and adult T-cell lymphoma) were reviewed.