Fanconi anemia protein and acute myeloid leukemia

VernacularTitle:范可尼贫血蛋白与急性髓系白血病
Author: Ye LOU ; Lihui ZHAN ; Hua FAN
Publication Type:Journal Article
Keywords: Fanconi anemia complementation group F protein; Egg white; Leukemia; Genes
From: Journal of Leukemia & Lymphoma 2009;18(5):315-317
CountryChina
Language:Chinese
Abstract: Fanconi anemia (FA) is an rare autosomal recessive inherited disease which manifests progressive marrow failure, congenital bone malformation, high risk to cancers and so on. Chromatin of FA cells display auto-instability and high hypersensitivity to interstrand DNA cross-links such as mitomycin C. As normally FA develop into acute myeloid leukemia easily, it has been regarded as pre-leukemia state. Till now 11 FA genes have been found and play a role in sustaining stability of gene groups through the same mechanism. As an active connecting protein, FANCF protein play an important part in correct FA complex formation. Which makes FANCD2 single ubiquitin. Ubiquitin FANCD2 induces chromatin and BRCA1 interact, and repair injured DNA. FA gene defect makes gene group instable and increases the risk of chromatin collapse, which finally leads to acute myeloid leukemia and myelodysplastic syndrome.