Significance of dysplasia and cytogenetic changes on the diagnosis and typing of myelodysplastic syndrome
10.3760/cma.j.issn.1009-9921.2012.07.007
- VernacularTitle:病态造血细胞与细胞遗传学改变对骨髓增生异常综合征诊断及分型的意义
- Author:
Ling LI
;
Ming JIANG
;
Hong CHENG
;
Shuang CHEN
;
Jianping HAO
;
Di ZHONG
;
Bingzhao WEN
- Publication Type:Journal Article
- Keywords:
Myelodysplastic syndrome;
Dysplasia;
Chromosome karyotype abnormal;
Diagnosis;
Typing
- From:
Journal of Leukemia & Lymphoma
2012;21(7):408-411
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the significance of dysplasia and cytogenetic changes to the diagnosis and typing of myelodysplastic syndrome (MDS).Methods The dysplasia performance of each series in every isoforms was observed by the bone marrow aspiration and peripheral blood smear to the 132 patients with MDS. At the same time do the chromosome karyotype was analizad combined with morbidness cells and chromosome karyotype abnormal analysis associated with MDS subtype. Resuits Acorrding to the dysplasia ≥0.10, the totle detection rate of granulocyte series, erythrocyte series and megakaryocytic was 43.4 ％.The morbidness granulocyte and megalokaryocyte ≥0.10was mainly in RCMD (P ＜ 0.01); morbidness erythrocytes≥0.10 mainly in RA + RARS (P ＜ 0.01). the totle detection rate of chromosome karyotype abnormal in MDS was 44.0 ％.The detection rate in RA and RARS was lower than other isoforms,but showed no statistically significant (P ＞ 0.05).the relationships of dysplasia and chromosome karyotype abnormal with the isoforms of MDS:in RA group,50.0 ％(3/6) patients had karyotype abnormal simultaneous the detection of morbidness cells≥0.10, 76.0 ％(19/25) in RCMD group and 60.9 ％(14/23) in RAEB group (P ＜ 0.01).Conclusion Theve is relationships between the patients with chromosome karyotype abnormal and dysplasia ≥0.10 and the isoforms of MDS. Closely monitoring the hemopoiesis and cytogenetic changes is significance to diagnose MDS.
