Strategies of the diagnosis and treatment of extranodal NK/T cell lymphoma, nasal type

VernacularTitle:鼻型结外NK/T细胞淋巴瘤的诊治策略
Author: Jingwen WANG ; Liqiang WEI
Publication Type:Journal Article
Keywords: Extranodal NK/T cell lymphoma; Diagnosis; Therapy
From: Journal of Leukemia & Lymphoma 2012;21(11):643-645
CountryChina
Language:Chinese
Abstract: Extranodal NK/T cell lymphoma,nasal type is a common subtype of non-Hodgkin's lymphomas in China.Many difficulties remain in its diagnosis and treatment.Correct diagnosis can be established according to the typical histology findings and immunology phenotypes with CD33（E）,EBER and/or CD56 positive.Prognostic factors should be assessed in the initiation of diagnosis.Ann Arbor staging classification has still being widely used and PET-CT scan is strongly recommended.Chemotherapy followed by radiotherapy should been considered for early-stage patients and combined chemotherapy is the best choice for advanced stage patients.The regimens containing L-asparaginase should be considered firstly due to the evidences from many clinical trials.Stem cell transplantation is recommended to almost all patients except for IE stage patients without any unfavorable prognostic factor.New regimens should be investigated and assessed in the perspective randomized clinical trials.