Magnetic resonance spectroscopy in observing thalamus metabolism of patients with multiple sclerosis or neuromyelitis optica
- VernacularTitle:磁共振波谱成像观察多发性硬化与视神经脊髓炎患者丘脑代谢产物
- Author:
Xuan CHEN
;
Yongmei LI
;
Tianyou LUO
;
Yu OUYANG
;
Fajin LV
;
Chun ZENG
;
Zhongping WANG
- Publication Type:Journal Article
- Keywords:
Neuromyelitis optica;
Multiple sclerosis;
Magnetic resonance spectroscopy;
Thalamus;
Differential diagnosis
- From:
Chinese Journal of Interventional Imaging and Therapy
2011;08(5):380-383
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the variation of thalamus metabolism in patients with multiple sclerosis (MS) or neuronmyelitis optica (NMO) using 1H-MRS.Methods1H-MRS was performed to 32 MS patients (MS group),28 NMO patients (NMO group) and 35 healthy volunteers (normal control group).The ratios of metabolism in thalamus,including N-acetylaspartic acid/creatine (NAA/Cr),choline/creatine (Cho/Cr) and myo-inositol/creatine (mI/Cr) were calculated and compared.ResultsThere was statistical difference of NAA/Cr in thalamus among the three groups (P＜0.05).NAA/Cr in thalamus of MS group was significantly lower than that of normal control group (t= -3.45,P＜0.05),while no statistical difference of Cho/Cr and mI/Cr was found (t=0.086,0.661,all P＞0.05).No statistical difference of NAA/Cr,Cho/Cr or ml/Cr was found between NMO group and normal control group (t=-0.792,1.408,1.735,all P＞0.05).Conclusion1H-MRS shows the decrease of thalamus NAA/Cr that suggesting axon damage in MS patients,but in NMO patients no same result is found.1 H-MRS can reflect the pathological changes of MS and NMO,and improve the differential diagnosis of the two diseases.
