Expression of the plasma IL-11 and soluble glycoprotein 130 in the patients with acute leukemia

VernacularTitle:急性白血病患者血清白细胞介素-11及可溶性糖蛋白130水平的测定
Author: Qiurong ZHANG ; Miao MIAO ; Depei WU ; Caixia LI ; Xiaojing WU ; Lingsong CHEN ; Ruonan CAO
Publication Type:Journal Article
Keywords: Leukemia,acute; Interleukin-11; Glycoproteins
From: Journal of Leukemia & Lymphoma 2008;17(2):103-104
CountryChina
Language:Chinese
Abstract: Objective To explore the levels and the significance of IL-11 and soluble glycoprotein 130(sgp130) in the treatment of new-diagnosed acute leukemia(AL) during the induced remission. Methods The levels of IL-11 and sgpl30 in 47 patients with acute leukemia were determined by ELISA respectively before treatment and after completed remission(CR), and the number of white blood cell (WBC) and platelet (Plt) were valued by hametometry. Results Plasma IL-11 level of AL patients was significantly lower than normal (P ＜0.05), and increased obviously to the normal level when complete remission was achieved. And it correlated with PLT counts. While sgp130 level was higher than normal (P＜0.05),and declined after CR and correlated with WBC counts. Conclusion The plasma IL-11 and sgp130 levels can be helpful for confirming the diagnosis,evaluating the efficiency and predicting the prognosis of AL.