Comparison of morphology, immunology and cytogenetics in adult acute leukemia of different ages
10.3760/cma.j.issn.1009-9921.2010.06.008
- VernacularTitle:不同年龄成年人急性白血病形态学、免疫学及细胞遗传学分型比较
- Author:
Wei WU
;
Guoqiang QIU
;
Haoqing WU
;
Zhilin WANG
- Publication Type:Journal Article
- Keywords:
Leukemia;
Adult;
Morphology;
Allergy and immunology;
Cytogenetics
- From:
Journal of Leukemia & Lymphoma
2010;19(6):344-346
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characters of morphology,immunology and cytogenetics of adult acute leukemia (AL) in different ages. Methods 172 cases of newly diagnosed adult AL were divided into two groups:the non-aged group (age＜60 years) and the aged group ( age≥60 years). Morphology,immunology and cytogenetics between the two groups were compared. Results The incidence of M3 in aged AL was significantly lower than that in non-aged AL[6.0 %(3/50) vs 18.9 %(23/122),P ＜0.05]. The incidence of hypo-or extremely hypo-cellular AL in aged AL was significantly higher than that in non-aged AL[14.0 %(7/50) vs 4.1 %(5/122),P ＜0.05],but the incidence of hyper-or extremely hyper-cellular was significantly lower than that in non-aged AL[52.0 %(26/50) vs 73.8 %(90/122),P ＜0.05]. Among aged acute myeloid leukemia (AML),the incidence of lymphoid antigen positive AML (Ly+AML) was significantly higher than that in non-aged AML[63.4 %(26/41) vs 41.3 %(38/92),P ＜0.05]. The incidence of adverse karyotypes in aged AML was significantly higher than that in non-aged AML[33.3 %(11/33) vs 14.1 %(10/71),P ＜0.05].Conclusion Age is an important prognostic factor in AL. Generally,aged AL has poorer prognosis than nonaged AL.
