Relationship between matrix metalloproteinase-9 expression and MRI characteristics of glioma
10.3321/j.issn:1003-3289.2009.12.014
- VernacularTitle:脑胶质瘤基质金属蛋白酶9表达与磁共振成像特征的相关性
- Author:
Lihua LIU
;
Ming ZHANG
;
Yuan WANG
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinase;
Magnetic resonance imaging;
Glioma
- From:
Chinese Journal of Medical Imaging Technology
2009;25(12):2197-2200
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the levels of matrix metalloproteinase-9 (MMP-9) expression in different grades of glioma and the relationship with MRI characteristics. Methods Thirty-one patients of glioma confirmed pathologically were divided into two groups: low grade group (grade Ⅰ and Ⅱ, n=20) and high grade group (grade Ⅲ and Ⅳ, n=11). MMP-9 expression levels were evaluated with immunohistochemical staining. Plain and enhanced MR scan were performed in all patients before operation. Peritumoral edema index (EI), enhance percentage (EP) and the tumor's maximum diameter were recorded as characteristics of MRI. Results The expression levels of MMP-9, EI, EP and the tumor's maximum diameter were significantly higher in the high grade group than those in the low grade group (t=6.312, 4.405, 6.286 and 5.026, respectively, all P＜0.05). The expression of MMP-9 were found significantly correlated to EI, EP and the maximum diameter of tumor (r=0.516, 0.554 and 0.676, respectively, all P＜0.05). The expression levels of MMP-9 were significantly different between tumors with heterogeneity and even signal (t=2.637, P＜0.05), but not between tumors with unclear border and clear border definition (t=0.906, P＞0.05). Conclusion MMP-9 expression have close relationship with invasion of glioma. EI, EP, the maximum diameter and signal of tumor can reflect the level of MMP-9 expression, and may be used to estimate tumor's malignant behavior, being able to provide the evidence for future clinical operation.
