Relationship between C-Reactive Protein and Atrial Fibrillation
10.3969/j.issn.0253-9896.2009.07.009
- VernacularTitle:C-反应蛋白及其-717A/G多态性与心房颤动的相关性
- Author:
Guiliang SHI
;
Min PAN
;
Jianhua WU
;
Jianhua ZHU
;
Xintao DENG
;
Jianxiang ZHAO
- Publication Type:Journal Article
- Keywords:
C-reactive protein;
polymorphism,genetic;
atrial fibrillation;
nephelometry and turbidimetry;
polymorphism,restriction fragment length;
polymerage chain reaction
- From:
Tianjin Medical Journal
2009;37(7):553-555
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship between C-reactive protein(CRP)and its-717MG polymorphismin atrial fibrillation(AD of the population of the city of Nantong.Methods:The relationships between AF and AF risk factors were analyzed by comparing genders,ages and body nlagS index(BWI)in 92 AF patients and 60 non-AF control subjects.The serum CRP levels were detected by immunoturbidimetry in of the two groups.The CRP-717MG polymorphism wa8 detected by polymerage chain reaction-restriction fragment-length polymorphism in patients and control subjects.Results:The sel3utm CRP level wag positively correlated with the left atrium internal diameter(LAD)in AF patient group(r=0.58,P＜0.01).The level of CRP Wag significantly higher in AF patient group compared with that of control group(P＜0.01).The serum CRP level Wag higher in patients with non-paroxysmal atrial fibrillation than that of patients with paroxysmal atrial fibrillation(P＜0.05).There Wag no significant difference in the frequency of CRP genotype between AF and control groups(P＞0.05).But the alleles frequency of the G Wag lower in AF group than that of control group(P＜0.05).Conclusion:The semm CRP level is associated with AF and its subgroups.The serum CRP level is positively correlated with LAD.The results suggest that the inflammation influences the AF though atrium reconstruction.The relationship between CRP-7 17A/G and AF stir needs further large-scale perspective studies.
