Histone methylation and hematological malignant
10.3760/cma.j.issn.1009-9921.2009.07.023
- VernacularTitle:组蛋白甲基化修饰与血液恶性肿瘤
- Author:
Yong ZOU
;
Xudong MA
- Publication Type:Journal Article
- Keywords:
Histone;
Methylation;
Hematological malignant
- From:
Journal of Leukemia & Lymphoma
2009;18(7):443-445
- CountryChina
- Language:Chinese
-
Abstract:
The N-terminal tail of histone exposed to the surface of nucleosomes could be covalcnfly modificated. Chromatin condensation is controlled by modification of the amino acid residues in the histone effects functionally on the nuclear processes and DNA expression. A large number of study show that improper change of the state of methylations in lysine and arginine side chains of histone can induce hematological malignant. Modulation of histone methylation can inhibit cell cycle and induce apoptosis in hematological malignant ceils.
