Assessment of therapeutic effect of anti-angiogenesis in rat C6 glioma with steady-state susceptibility contrast-enhanced MR perfusion imaging
- VernacularTitle:对比剂稳态磁化率MR灌注成像评价大鼠C6胶质瘤抗血管生成治疗的疗效
- Author:
Hongtao NIU
;
Wenli ZHANG
;
Qiyong GUO
;
Bing YU
;
Li MA
- Publication Type:Journal Article
- Keywords:
Glioma;
Endostastin;
Magnetic resonance imaging;
Angiogenesis
- From:
Chinese Journal of Medical Imaging Technology
2010;26(3):425-428
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the of value steady-state susceptibility contrast-enhanced MRI (SSCE-MRI) in assessment of anti-angiogenesis therapy in rat C6 glioma. Methods Seventeen rats with the bearing-tumor were randomly divided into the therapy group (n=8) and the contrast group (n=9). Human-recombination endostatin (10 mg/kg) was injected to animals in therapy group, and saline of the same dose was injected to the contrast group for 7 days. Blood volume (BV) and vessel size index (VSI) were measured of tumors in peripheral, central and normal areas with MR pre- and post-therapy. Results After therapy of endostatin, the tumor volume was obviously different between therapy group and contrast group (t=5.26, P<0.05). BV and VSI_(MRI) of tumor decreased in both peripheral and central areas, particularly in the peripheral area (t=4.14, 3.66, all P<0.01). Conclusion Assessment of therapeutic effect of anti-angiogenesis in C6 glioma is feasible with SSCE-MRI, and it can reflect the changes of BV and VSI_(MRI) pre- and post-therapy.
