Subtraction computed tomographic perfusion imaging and observation of ischemic necrosis of femoral head on dog
10.3321/j.issn:1003-3289.2009.07.002
- VernacularTitle:减影CT灌注成像技术及对犬股骨头坏死观察应用
- Author:
Xiujun YANG
;
Qile REN
;
Wei LI
;
Wenjuan XU
- Publication Type:Journal Article
- Keywords:
Femoral head necrosis;
Models,animal;
Tomography,X-ray computed;
Perfusion;
Subtraction technique
- From:
Chinese Journal of Medical Imaging Technology
2009;25(7):1131-1133
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the technical protocols and feasibility of subtraction computed tomography perfusion imaging (sCTP) on observation of ischemic necrosis of femoral head (ANFH) on dog. Methods Sixteen laboratory canines underwent CT perfusion imaging (CTP) of femoral head before and after selective femoral circumflex artery embolization, and ANFH were observed. Then new sequence imaging data, created by sources imaging of CT perfusion scan using subtraction software, were analyzed at workstation (AW 4.2) with CT perfusion 3 analysis program, and data of sCTP were obtained. The parametric maps and indexes of capillary-level hemodynamics including blood volume (BV), blood flow (BF) and mean transit time (MTT) of CTP and sCTP were compared. Results ①The technical success rate of sCTP post-processing created from CTP sources imaging data was 100%. The values and mappings of BF, BV and MTT of region of interest (ROI) were all obtained from subtraction sequence images data. The post-processing time of sCTP was about 1-5 h. ② sCTP depicted ANFH well, though the values and mappings of BF, BV and MTT were different from those obtained with conventional bone CTP. Conclusion sCTP can be generated with subtraction and perfusion analysis program and techniques. It can be applied to bone CT perfusion imaging and early quantitative diagnosis of necrosis.
