The study of induction and differentiation of leukemic cell by phorbol ester

VernacularTitle:佛波酯对白血病细胞诱导分化的研究进展
Author: Xiaoli YUAN ; Quande LIN ; Xudong WEI
Publication Type:Journal Article
Keywords: Leukemia; Cell differentiation; Phorbol ester
From: Journal of Leukemia & Lymphoma 2008;17(2):155-158
CountryChina
Language:Chinese
Abstract: 12-O-tetradecanoylphorbol-13-acetate (TPA) is an activator of protein kinase C (PKC)extracted from the croton oil, it is one of the most powerful inducers of differentiation as well as a powerful tumor promoter. It is used by the study of induction and differentiation generally, because of it can induce the differentiation of tumor cell and promote the lymphocyte transformation and secrete of lymphokine, meanwhile,it is able to induce many kinds of cell of leukemic cell strain like HL-60, HEL and so on, Some literature reported that TPA had the function of differentiation of primary leukemic cell. The article mainly explains the induction and differentiation of leukemic cell by phorbol ester as well as its mechanisms, which to provide the theory evidence for prevention and cure of leukemia.