Analysis of Expression of Multidrug Resistance Gene and Multidrug Resistance-Associated Protein Gene in Patients with Non-small-cell Lung Cancer
10.3969/j.issn.0253-9896.2000.12.012
- VernacularTitle:48例非小细胞肺癌MDR1及MRP基因表达结果分析
- Author:
Guangming ZHANG
;
Jianli TIAN
- Publication Type:Journal Article
- Keywords:
carcinoma;
non-small-cell lung lung neoplasms gene expression polymerase chain reaction
- From:
Tianjin Medical Journal
2000;28(12):738-739
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of multidrug resistance (MDR1) gene and multidrug resistance-associated pro-tein (MRP) gene in patients with non-small-cell lung cancer (NSCLC) and its relation to histopathological type. Methods:The MDRi and MRP genes were determined by reverse transcription-polymerase chain reaction (RT-PCR) in 48 NSCLCspecimens. Results:The positive rates of the MDR1 and MRP gene expression were 62.5％ and 66.7％ respectively in the48 patients. Twenty-one of the 48 NSCLCs (43.8％) expressed both MDR1 and MRP genes. The positive rates of the MRPgene expression in squamous cell carcinoma was significantly higher than those in adenocarcinoma (P＜0.01), and therewas no significant difference in MDR1 gene expression between the two groups (P＞0.05). Conclusion: The MDR1 andMRP gene expressions were both or respectively in the NSCLCs. The incidence of the MRP gene expression in squamous cellcarcinoma was higher than that in adenocarcinoma.
