Clinical analysis of mixed acute leukemia

VernacularTitle:急性混合细胞白血病38例临床研究
Author: Yuanyuan SHEN ; Zhimin ZHAI ; Qing LI ; Weibo ZHU ; Xiucai XU ; Zimin SUN ; Zhiwei WU ; Jingsheng WU
Publication Type:Journal Article
Keywords: Leukemia,mixed-cell; Immunophenotyping; Prognosis
From: Journal of Leukemia & Lymphoma 2008;17(5):361-363
CountryChina
Language:Chinese
Abstract: Objective To analyze the clinical and biological features of mixed acute leukemia(MAL).Methods Bone marrow specimens of 38 MAL patients were evaluated to prove the diagnosis and the classification by morphoiogic,immunologic examinations.These patients were treated with protocols suitable for both acute myeloid leukemia(AML)and acute lymphoblastic leukemia(ALL).Results All MAL patients had a leukemia syndrome.Morphologically,the subtypes of M1,M2 and M5 were predominant in AML,as L2 Was in ALL.Immunologically,coexpression of myeloid and B lineage associated antigens was predominant,about 68.4%;cytogenetically,Ph chromosome was observed in 33.3%(5/15)of MAL patients,and immunophenotype was B-M;1 Ph chromosome(+)MAL patient,fusion gene bcr-abl 190(+)and immunophenotype was B-M.In 38 cases,32 patients received chemotherapy.The complete remission rate was 28.1%(9/32).CR of.normal karyotype was significantly higher than that of abnormal ones.Conclusion Patients with MAL have unique biological features and the complete remission rate was low and the prognosis was poor.