Clinical investigation of idarubicin to intensify the MAC preparative regimens of autologous peripheral blood stem cell transplantation for patients with acute myeloid leukemia
10.3760/cma.j.issn.1009-9921.2009.12.012
- VernacularTitle:以IMAC预处理方案的自体外周血干细胞移植治疗急性髓细胞白血病的临床观察
- Author:
Chongchong XUE
;
Liping YANG
;
Guohong SU
;
Juan WANG
;
Weiying WEN
;
Huilan HUANG
;
Xiang WEI
;
Xiuyong WEN
;
Jianjun LIAO
;
Jixian HUANG
- Publication Type:Journal Article
- Keywords:
Peripheral blood stem cell transplantation;
Leukemia;
myelocytic;
acute;
Drug therapy;
combination
- From:
Journal of Leukemia & Lymphoma
2009;18(12):744-745
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of idarubiein to imensify the MAC (IMAC) as preparative regimen for autologous peripheral blood stem cell transplantation(APBSCT)in acute myeioid leukemia.Methods Fourteen patients with acute myeloid leukemia who underwent APBSCT were analysed. IMAC was used as preparative regimens.Results All patients were engrafted successfully.The disease-free survival could be Ben in 8 cases(57.1%),the median disease-free survival duration were 26(8-72)months and no treatment-related mortality was present.Conclusion This study suggested that addition of Idarubicin to the MAC preparative regimens Was safe,effective and feasible for patients with acute myeloid leukemia,and may improve disease-free survival and overall survival.
