Novel progress of epigenetic modification in leukaemia
10.3760/cma.j.issn.1009-9921.2009.05.021
- VernacularTitle:表观遗传学在白血病研究中的新进展
- Author:
Huanchen CHENG
;
Lin QIU
;
Jun MA
- Publication Type:Journal Article
- Keywords:
Leukemia;
Methylation;
Acetylation;
Genetics
- From:
Journal of Leukemia & Lymphoma
2009;18(5):309-312
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies indicated that epigenetic abnormality is the important molecular mechanism in leukemia. The change of epigenetic modification occurs in most kinds of leukaemia. Based on the epigenetic modification, the therapies of leukemia with hypomethylating agents and histone deaeetylases inhibitors, which are different from traditional chemotherapy are applied in the treatment of leukemia at beginning. The aim of this article is to summarize the recent advances of DNA methylation and histone modification in leukaemia occurrence, treatment and prognosis.
