Apolipoprotein E polymorphism in northern Chinese elderly patients with coronary artery disease
- Author:
Yangchun ZOU
;
Dayi HU
;
Xiufang HONG
;
Xingyuan JIA
;
Xinchun YANG
;
Liang CUI
- Publication Type:Journal Article
- Keywords:
apolipoprotein E;
DNA-polymorphism;
elderly;
coronary artery disease
- From:
Journal of Geriatric Cardiology
2006;3(2):95-98
- CountryChina
- Language:Chinese
-
Abstract:
Background and objective Apolipoprotein E is a constituent of lipoproteins with considerable variation due to cysteine-arginine exchanges. We investigated the relationship between apo E gene polymorphism and the occurrence of coronary artery disease(CAD) in the older population of northern China. Methods The distribution of the HhaI polymorphisms of the apolipoprotein E gene was determined among 55 patients with CAD (CAD group), which was compared with that of 36 elderly subjects without CAD(control group). Results Genotype distributions at both sites (apo E gene 112-bp and 158-bp sites ) were different between the CAD and control groups. The CAD group had lower apolipoprotein Eε2frequencies than the control group (P＜0.05). Conclusion Individuals with apolipoprotein Eε2are likely to have a reduced risk of developing coronary artery disease as demonstrated by elderly subjects in Northern China.
