Chromosome 13 abnormalities and multiple myeloma
10.3760/cma.j.issn.1009-9921.2010.07.019
- VernacularTitle:13号染色体异常与多发性骨髓瘤
- Author:
Yanying WANG
;
Gang AN
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Chromosome 13 abnormalities;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2010;19(7):438-440
- CountryChina
- Language:Chinese
-
Abstract:
With the development of FISH and other technique, the detection rate of chromosome abnormalities in multiple myeloma (MM) were increased. Chromosome 13 abnormalities is most common feature (about 50 %). The tumor suppressor gene and micro RNA on chromosome 13 play an important role on pathogenesis of MM. In the last decade, it is widely believed that chromosome 13 abnormalities is independent poor prognosis factor, but the recent more studies conform that its prognosis value is dependent on the other chromosome abnormalities. It is found that the new drugs such as bortezomib appear to reverse the poor prognosis conferred by chromosome 13 deletion.
