Expressions of ZAP-70 and CD38 in chronic B lymphocytic leukemia and their clinical significance

VernacularTitle:ZAP-70及CD38在慢性B淋巴细胞白血病中表达的意义
Author: Xiaowei LAI ; Linhua YANG ; Lanmin YANG ; Lie ZHU ; Li ZHANG ; Lihong HOU ; Zhenhua QIAO
Publication Type:Journal Article
Keywords: Leukemia,lymphocytic,chronic; Prognosis; ZAP-70; CD38
From: Journal of Leukemia & Lymphoma 2009;18(4):231-233
CountryChina
Language:Chinese
Abstract: Objective To detect the ZAP-70 and CD38 expression in these patients with chronic B lymphocytic leukemia (B-CLL) and explore their relationship and clinical significance. Methods The expressions of ZAP-70 and CD38 in bone marrow or peripheral blood of 21 patients with B-CLL were detected by flow cytometry. Results ZAP-70 was positively expressed in 9 of all patients, CD38 was positive in 8 of all patients. ZAP-70 and CD38 were both expressed in 8 patients, ZAP-70 and CD38 were none expressed in 8 patients. Conclusion CD38 and ZAP-70 expression can offer important prognostic information. Cases of B-CLL positive for ZAP-70 and CD38 indicate a worse prognosis. There is a good correlation between these new prognostic factors.