Progress in the studies of leukemia stem cell
10.3760/cma.j.issn.1009-9921.2008.03.025
- VernacularTitle:白血病干细胞研究进展
- Author:
Ruirong XU
- Publication Type:Journal Article
- Keywords:
Leukemia;
Stem cells;
Therapy
- From:
Journal of Leukemia & Lymphoma
2008;17(3):228-230
- CountryChina
- Language:Chinese
-
Abstract:
Acute myelogenous leukemia (AML) cells are organized in a hierarchical fashion, with only the most primitive rare population (leukemia stem cell, LSC) of AML cells capable of maintaining the leukemic clone. Due to a predominantly G0 cell-cycle status, LSC may not be responsive to conventional chemotherapeutic agents.compared with leukemia blasts. It is proposed that surviving LSC are a major contributing factor to leukemia relapse. This article reviewed the data emerging from the study of LSC, elucidated the distinct cellular and molecular characteristics of the LSC population,and the target therapy of LSC, which may shed new light on AML therapy and leukemogenesis study.
