Overexpression and clinical implication of MDM2 oncogene in acute leukemia

VernacularTitle:癌基因MDM2 mRNA在急性白血病的过度表达及其临床意义
Author: Qianru LI ; Liping SU ; Jingping ZHANG ; Jianrui WU ; Mingli LI ; Meijing ZHENG ; Jingjing DUAN ; Yongan ZHOU
Publication Type:Journal Article
Keywords: Leukemia,acute; Proto-oncogene proteins C-MDM2; Prognosis
From: Journal of Leukemia & Lymphoma 2010;19(6):341-343
CountryChina
Language:Chinese
Abstract: Objective To study the over-expression and clinical implications of the oncogene MDM2 in acute leukemia (AL). Methods The expression of MDM2 gene in 100 patients with newly diagnosed and relapse or refractory AL and 20 healthy as control was measured by relative quantitative reverse transcriptase polymerase chain reaction (RT-PCR),then the results was measured by χ2-test,t-test and one-way ANOVA to compare expession positive rate and intensity of MDM2. Results Among 100 patients,fifty-eight had the high expression of MDM2 gene (58 %). The expression level of MDM2 gene in patients was higher than that of health controls(P ＜0.05). The expression positive rate of MDM2 is higher in poor outcome group (67.9 %,19/28)than that in general outcome group (33.9%,19/56) (P＜0.05). Conclusion Our results suggest that the expression of MDM2 gene plays an important role in the pathogenesis and poor outcome of AL.