A new therapeutic strategy in myelodysplasia syndromes: modification of the epigenome

VernacularTitle:骨髓增生异常综合征的治疗新策略——表观基因调控
Author: Xing CUI ; Ruirong XU ; Junqiang WANG
Publication Type:Journal Article
Keywords: Myelodysplastic syndromes; Epigenetics; DNA hypomethylate; Histone deacetylase inhibitors
From: Journal of Leukemia & Lymphoma 2009;18(10):633-635
CountryChina
Language:Chinese
Abstract: The term epigenetics refers to a number of biochemical modifications of chromatin that, without altering the primary sequence of DNA, play a role in genomic regulation and in control of particular gene expression. These modifications involve several kinds, such as DNA methylation, histone code modifications and chromatin remodeling. It is accepted that these modifications is as common in solid tumors as it is in hematologic malignancies such as myelodysplastic syndromes(MDS). So many specialists suggest that the study of this area is very valuable. The current clinical information regarding different forms of epigenetic therapy in patients with MDS were focused in this review.