Clinicopathological study of cutaneous anaplastic large cell lymphoma complicated with acute myeloid leukemia
10.3760/cma.j.issn.1009-9921.2010.08.007
- VernacularTitle:皮肤原发性间变性大细胞淋巴瘤合并急性髓细胞白血病一例并文献复习
- Author:
Xiaojing AN
;
Bo WU
;
Hangbo ZHOU
;
Qunli SHI
;
Xiaojun ZHOU
- Publication Type:Journal Article
- Keywords:
Lymphoma,T-cell,cutaneous;
Leukemia,myeloid;
Immunohistochemistry
- From:
Journal of Leukemia & Lymphoma
2010;19(8):475-478
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the morphological, immunohistochemical characters and prognosis in one case of patients with cutaneous anaplastic large cell lymphoma complicated with acute myeloid leukemia (C-ALCL-AML). Methods The histopathology, immunohistochemical markers and follow-up information of one case of ALCL-AML was analyzed and the correlated literature was reviewed. Results The patient, 69 year-old, female, was initially present with shin lesion on one finger and abnormal myelogram. The histopathology of shin lesion showed that tumor cells were composed of large cells with abundant cytoplasm,the nuclei were large and irregular, and were infiltrated by Neutrophil and eosinophil. The CD30,CD3 and CD43 of tumor cells were positive, but ALK negative by immunohistochemical method. The number of WBC in peripheral blood was 15.5×109/L and 51 archaeocytes were in every 100 karyotes. Bone marrow aspiration detection showed that bone marrow was hyperplasia and the ratio of myeloblast was 78 %. This patient was diagnosed as C-ALCL-AML, partly differentiation type(AML-M2a). Conclusion C-ALCL-AML is very rare. Its diagnosis is dependent on clinical data, histopathology and immunohistochemical markers. The first choice of treatment is chemotherapy, but its prognosis is poor.
