Clinical observation on short-term efficacy of MINE regimen for patients with recurrent and refractory NHL

VernacularTitle:MINE方案解救治疗复发或难治性非霍奇金淋巴瘤近期疗效观察
Author: Dongxia HU ; Xiaoli ZHANG ; Yingli CHEN
Publication Type:Journal Article
Keywords: Lymphoma,non-Hodgkin; Antineoplastic combined chemotherapy protocols; Treatment outcome
From: Journal of Leukemia & Lymphoma 2009;18(7):412-414
CountryChina
Language:Chinese
Abstract: Objective To investigate the efficacy and side effects of MINE regimen, as a salvage regimen, in treating patients with recurrent and refractory intermediate grade non-Hodgkin lymphoma(NHL).Methods 45 patients failing to CHOP or CHOP-like regimen were treated with MINE regimen and every patient had received 2-6 cycles of treatment. IFO 15 g/m2, ivgtt on d1-3, combined with mesna 400 mg iv for3 times on Oh, 4h, 8h after IFO ivgtt; MIT 10 mg/m2 ivgtt on dl; VP1665 mg/m2 ivgtt on d1-3. 21-28 daysconsisted of one cycle. The therapeutic effects and side effects were evaluated according to the WHO criteria.Results In all 45 patients, 53.3 % of overall response rate were achieved CR for 9 cases, 15 cases PR, 13 cases SD and 8 cases PD. Main side effects were myelosuppression, nausea, vomit, alopecia, etc. Conclusion MINE regimen is an effective and safe salvage regimen in treating patients with recurrent and refractory intermediate grade NHL. Further clinical study on the application of MINE regimen is recommended.