Clinical significance of CD4+CDHi25 regulatory T cells in childhood acute leukemia

VernacularTitle:CD4+CD25高表达调节性T细胞与儿童急性淋巴细胞白血病的关系
Author: Aimei ZHANG ; Zhimin ZHAI ; Ningling WANG ; Qing LI ; Xiucai XU ; Zhiwei WU ; Cuiping ZHANG ; Huiping WANG
Publication Type:Journal Article
Keywords: Leukemia,lymphocytic,acute; Child; T-Lymphocytes,regulatory
From: Journal of Leukemia & Lymphoma 2008;17(4):267-270
CountryChina
Language:Chinese
Abstract: Objective To evaluate the proportion and clinical significance of CD4+CD25+ regulatory T cells in childhood acute lymphocyte leukemia(AEL)during different therapeutic stages.Methods 55 peripheral blood samples from 40 children patients with ALL were detected by muhiparameter flow cytometry with fluoresce-hbeled monoclonal antibody.Results Treg cells phenotypically express not only CD62L but also FoxP3 protein.In patients with ALL standard-risk the proportion of CD4+CD25Hi was(1.04±0.33)% in the first course of induction treatment, (1.60±0.44)% in maintenance treatment groups, and(1.29±0.30)% in complete remission groups respectively,while in patients with ALL the intermediate and high risk during maintenance therapy was(2.24±0.75)%.Conclusion Compared with healthy children,the proportion of Treg ceHs in ALL is significantly higher,and may be related to the effect of chemical treatment and severity of ALL.The elevated proportion of Treg may contribute to disease relapse.