Using Ig/TCR gene rearrangements to monitor minimal residual disease in pediatric lymphoma
10.3760/cma.j.issn.1009-9921.2010.11.019
- VernacularTitle:应用Ig/TCR重排监测儿童淋巴瘤微小残留病
- Author:
Yanping XING
- Publication Type:Journal Article
- Keywords:
Ig/TCR rearrangement;
Neoplasm,residual;
Real-time quantitative PCR
- From:
Journal of Leukemia & Lymphoma
2010;19(11):695-698
- CountryChina
- Language:Chinese
-
Abstract:
Detection of minimal residual disease (MRD) exactly for lymphoma is important for estimating prognosis, assessing response, monitoring relapse and instructing treatment. Immunoglobulin (Ig)/T-cell receptor (TCR) gene rearrangements can be used as special tumorous markers for MRD testing by PCR.BIOMED-2 strategy is a method about multiplex PCR reaction designed by European Collaborative Organization. Monitoring MRD can be completed by real-time quantitative PCR. In this paper, the principle and research progress related to the application of IG/TCR in MRD detection are mainly reviewed for lymphoma in children.
