Influence of various doses and injection rates of contrast agent on CT perfusion in rabbits' liver with deconvolution method
- VernacularTitle:对比剂剂量及注射流率对去卷积法兔肝脏CT灌注值的影响
- Author:
Jingkun XIAO
;
Bin LIU
;
Wanqin WANG
;
Lei FANG
;
Xingwang WU
;
Yongqiang YU
- Publication Type:Journal Article
- Keywords:
Liver;
Tomography,X-ray computed;
Perfusion imaging;
Contrast media
- From:
Chinese Journal of Medical Imaging Technology
2010;26(4):612-615
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of various doses and injection rates of contrast agent on CT perfusion in rabbits' liver with a deconvolution mathematical model. Methods Eight rabbits were enrolled in the experiment. Randomized block design was adopted. The treatment factor (contrast medium injection rate) was classified into 0.5, 1.0, 1.5 ml/s, while the subjects were divided into 3 blocks with contrast medium injection dose of 0.5, 1.0 and 1.5 ml/kg. The data obtained at CT perfusion imaging were then transferred to the workstation. Absolute values of 7 perfusion parameters (hepatic arterior fraction, blood flow, blood volume, permeability surface, mean transmit time, hepatic artery perfusion and portal vein perfusion) were measured with perfusion software (Perfusion 3). Results The dose of contrast medium had significant effect on peak enhancement of the aorta, the portal vein and liver tissue (P<0.05), whereas the injection rates had significant influence on the arrival time to peak enhancement of the aorta and the portal vein. However, the dose of contrast medium and injection rates had no significant effect on perfusion parameters (P>0.05). Conclusion CT perfusion imaging with a deconvolution mathematical model can quantify the hemodynamic functional status in liver with stable results. This technique does not need strict confinement to dose and injection rate of contrast medium, and has great potential value to be put into clinical use.
