Correlative study among CT signs, prognosis and the expression of CD44v3 and CD44v6 in peripheral non-small-cell lung cancer
10.3321/j.issn:1003-3289.2009.07.020
- VernacularTitle:周围型非小细胞肺癌CT征象、预后与CD44v3、CD44v6表达的相关研究
- Author:
Xuhui ZHANG
;
Liangping LUO
;
Xulong ZHOU
;
Jincheng CHEN
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Immunohistochemistry;
Tomography,X-ray computed;
Prognosis
- From:
Chinese Journal of Medical Imaging Technology
2009;25(7):1195-1198
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the relationship between CT signs, prognosis and the expression of CD44v3 and CD44v6 in peripheral non-small-cell lung cancer (NSCLC). Methods The expression of CD44v3 and CD44v6 was detected with immunohistochemistry (SP method) in 46 patients with peripheral NSCLC confirmed by surgery and pathology. The expression, CT signs and prognosis of NSCLC were analyzed respectively. Results The expression of CD44v3 and CD44v6 correlated with deep lobulation, spinous protuberant sign, short spiculation and lymph node enlargement of hila or mediastinum (P<0.05), but not with the tumor size, vacuole sign, vessel convergence sign and pleural indentation in CT images of peripheral NSCLC (P＞0.05). The expression of CD44v3 and CD44v6 correlated with the three-year survival rate in peripheral NSCLC patients (P<0.05). Conclusion Deep lobulation, spinous protuberant sign, short spiculation and lymph node enlargement of hila or mediastinum may indicate strong potential invasion and metastasis in peripheral NSCLC. The positive expression of CD44v3 and CD44v6 may suggest shorter survival time and poorer prognosis in peripheral NSCLC patients.
